Krause K H, Berlit P, Bonjour J P
Arch Psychiatr Nervenkr (1970). 1982;231(2):141-8. doi: 10.1007/BF00343835.
Of 117 patients treated with anticonvulsants reduced plasma biotin levels were found in over 80% of cases. Significant negative correlations with the average daily dose and the total amount of anticonvulsants as well as with the plasma phenytoin level were also evident. It is proposed that the lowering of biotin--which is a co-factor of the carboxylating enzyme system--is an important mechanism in mode of action of anticonvulsants. Reduced biotin levels possibly lead to an accumulation of carbon dioxide or a diminution of aspartate in brain tissue. Low biotin levels may also be the cause of some well known side effects of anticonvulsants such as cerebellar disturbances and dermatitis. In comparison to the other epileptics the patients with cerebellar symptoms showed significantly lowered plasma biotin levels.
在117例接受抗惊厥药物治疗的患者中，超过80%的病例血浆生物素水平降低。与抗惊厥药物的平均日剂量、总量以及血浆苯妥英水平也存在显著负相关。有人提出，生物素（羧化酶系统的一种辅助因子）水平降低是抗惊厥药物作用机制中的一个重要机制。生物素水平降低可能导致脑组织中二氧化碳积聚或天冬氨酸减少。低生物素水平也可能是抗惊厥药物一些众所周知的副作用的原因，如小脑功能障碍和皮炎。与其他癫痫患者相比，有小脑症状的患者血浆生物素水平显著降低。
