Krause K H, Berlit P, Bonjour J P
Ann Neurol. 1982 Nov;12(5):485-6. doi: 10.1002/ana.410120513.
In 264 epileptics undergoing long-term therapy with anticonvulsants, significantly reduced plasma biotin levels were found compared with a normal control group: 74% of the epileptics had biotin levels of 250 ng/L or less. In patients undergoing single-drug therapy, the mean plasma biotin levels for those treated with sodium valproate were higher than for those treated with phenytoin, primidone, or carbamazepine. The observed reduction in biotin levels might be a factor influencing the efficacy of these three anticonvulsants.
在264名接受抗惊厥药物长期治疗的癫痫患者中，与正常对照组相比，发现血浆生物素水平显著降低：74%的癫痫患者生物素水平为250 ng/L或更低。在接受单一药物治疗的患者中，丙戊酸钠治疗患者的平均血浆生物素水平高于苯妥英钠、扑米酮或卡马西平治疗的患者。观察到的生物素水平降低可能是影响这三种抗惊厥药物疗效的一个因素。
