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实验诱导补体和免疫球蛋白沿基底膜带(BMZ)及真皮血管沉积。

Experimentally induced complement and immunoglobulin deposition along the basement membrane zone (BMZ) and in dermal blood vessels.

作者信息

Miller R A, Griffiths W A

出版信息

Br J Dermatol. 1982 Mar;106(3):275-9. doi: 10.1111/j.1365-2133.1982.tb01723.x.

DOI:10.1111/j.1365-2133.1982.tb01723.x
PMID:7066187
Abstract

Clinically normal forearm skin of ten subjects was abraded and biopsied at 24 h and at 5 and 10 day intergvals. Biopsy specimens were processed for routine histology and direct immunofluorescence. All ten subjects showed deposition of complement either in the blood vessels and/or along the basement membrane zone 24 h after injury. IgM deposition was found along the BMZ in two patients and in the blood vessels of the papillary dermis in one patient. This immunofluorescence staining was considered a non-specific reaction pattern to injury.

摘要

对10名受试者临床正常的前臂皮肤进行擦伤处理,并在24小时以及5天和10天的间隔时间进行活检。活检标本进行常规组织学和直接免疫荧光处理。所有10名受试者在受伤后24小时均显示补体在血管和/或沿基底膜带沉积。在两名患者中发现IgM沿基底膜带沉积,在一名患者的乳头真皮血管中发现IgM沉积。这种免疫荧光染色被认为是对损伤的非特异性反应模式。

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