Bosman G J, Boer P, Steyn-Parvé E P
Biochim Biophys Acta. 1982 Mar 29;696(3):285-9. doi: 10.1016/0167-4781(82)90059-8.
Tunicamycin, 2-deoxy-D-glucose and 2-deoxy-2-fluoro-D-glucose inhibit dimethyl sulfoxide-induced differentiation of Friend cells. This inhibition, characterized by inhibition of hemoglobin synthesis, is accompanied by a specific inhibition of protein glycosylation. The results of cloning experiments indicate that this inhibition specifically affects cells in the period preceding their commitment. These results suggest that glycoprotein synthesis is a requirement for Friend erythroleukemia cells in order to initiate the expression of the terminal differentiation program.
衣霉素、2-脱氧-D-葡萄糖和2-脱氧-2-氟-D-葡萄糖可抑制二甲基亚砜诱导的弗氏细胞分化。这种抑制作用以血红蛋白合成受抑制为特征，同时伴有蛋白质糖基化的特异性抑制。克隆实验结果表明，这种抑制作用特异性地影响细胞在其定向分化之前的阶段。这些结果提示，糖蛋白合成是弗氏红白血病细胞启动终末分化程序表达所必需的。
