Yoshioka T, Mori M, Takehara Y, Shimatani M
Biol Neonate. 1982;41(3-4):155-60. doi: 10.1159/000241545.
The excessive accumulation of lipoperoxides has been accepted as being highly responsible for the development of retinopathy of prematurity and idiopathic respiratory distress syndrome of the newborn infant. We have studied development-related levels of lipoperoxides in blood and tissues such as the liver, lungs, kidneys and brain from birth to adult age using rats as the experimental animal. Lipoperoxide concentrations in blood and tissues were low in fetal and early newborn periods. The concentrations increased with age and peaked in the early newborn period and gradually decreased as the development progressed. In vitro lipoperoxide formation and accumulation in tissues exhibited a close correlation with in vivo lipoperoxide concentrations, except in the brain.
脂质过氧化物的过度积累被认为是早产儿视网膜病变和新生儿特发性呼吸窘迫综合征发生的重要原因。我们以大鼠为实验动物，研究了从出生到成年期血液和肝脏、肺、肾、脑等组织中与发育相关的脂质过氧化物水平。胎儿期和新生儿早期血液和组织中的脂质过氧化物浓度较低。这些浓度随年龄增长而增加，在新生儿早期达到峰值，并随着发育进程逐渐下降。除大脑外，组织中体外脂质过氧化物的形成和积累与体内脂质过氧化物浓度密切相关。
