Boiarinov G A, Peretiagin S P, Efremenko V A, Kosenkova I T, Solotsinskiĭ S S
Biull Eksp Biol Med. 1982 Feb;93(2):35-8.
Experiments of 34 dogs were made to study alterations in the cardio- and hemodynamics and microcirculation in the mesenterium during hypotension caused by hemorrhage after intravenous injection of sodium hydroxybutyrate and intravenous re-infusion of heparinized blood under a pressure of 80-120 mm Hg. It was established that single injection of sodium hydroxybutyrate in a dose of 180-200 mg/kg after a 60-minute decrease in the arterial pressure to 40 mm Hg increases pump function of the heart, venous blood returns to the heart, and improves microcirculation. This improvement manifests by the rise in the blood flow rate in the microvessels and in the number of functioning capillaries, and by diminution of red cell aggregation. Favourable effect of the drug is seen within the first minutes after injection and remains unchanged for one hour. Intravenous blood pumping under long-term hypotension is an effective approach to making for the lost blood in the presence of the preceding injection of sodium hydroxybutyrate.
对34只狗进行实验，以研究静脉注射羟丁酸钠后出血所致低血压期间，肠系膜的心脏和血流动力学以及微循环的变化，以及在80 - 120毫米汞柱压力下静脉再输注肝素化血液的情况。结果表明，在动脉压降至40毫米汞柱60分钟后，单次注射剂量为180 - 200毫克/千克的羟丁酸钠，可增强心脏泵功能，使静脉血回流至心脏，并改善微循环。这种改善表现为微血管内血流速度加快、功能正常的毛细血管数量增加以及红细胞聚集减少。药物的有益作用在注射后的最初几分钟内即可显现，并持续一小时不变。在先前注射羟丁酸钠的情况下，长期低血压时静脉输血是补充失血的有效方法。
