Weiss N S, Daling J R, Chow W H
Cancer. 1982 Apr 15;49(8):1713-5. doi: 10.1002/1097-0142(19820415)49:8<1713::aid-cncr2820490830>3.0.co;2-y.
As part of an epidemiologic study of cancer of the large bowel in women, female residents of King and Pierce counties (Washington) who were diagnosed during 1976--77 were interviewed regarding previous gallbladder surgery. Their responses were compared with those of a random sample of women from the same population. A history of cholecystectomy was somewhat more frequent among patients with colon cancer than among controls--we estimate the colon cancer risk in women without a gallbladder to be 1.4 times that of other women--but the 05% confidence limits of the relative risk included 1.0 (0.8--2.5). There was no association between cholecystectomy and rectal cancer and, among the subsites of colon cancer, the magnitude of the excess risk failed to show any consistent right--left gradient. Nonepidemiologic data suggest that cholecystectomy could increase the risk of colon cancer. However, if such an association truly exists it is not a strong one, and studies larger than those conducted to date are needed to detect this association reliably.
作为一项针对女性大肠癌的流行病学研究的一部分，对1976 - 1977年间在华盛顿州金县和皮尔斯县被诊断出患有该病的女性居民就其既往胆囊手术情况进行了访谈。将她们的回答与来自同一人群的随机抽样女性的回答进行了比较。结肠癌患者中有胆囊切除术史的情况比对照组略为常见——我们估计无胆囊女性患结肠癌的风险是其他女性的1.4倍——但相对风险的95%置信区间包含1.0（0.8 - 2.5）。胆囊切除术与直肠癌之间没有关联，在结肠癌的亚部位中，额外风险的程度未显示出任何一致的右 - 左梯度。非流行病学数据表明胆囊切除术可能会增加患结肠癌的风险。然而，如果这种关联确实存在，它也并不强烈，需要开展比迄今所进行的研究规模更大的研究才能可靠地检测到这种关联。
