Papadimitriou C, Day N, Tzonou A, Gerovassilis F, Manousos O, Trichopoulos D
Int J Epidemiol. 1984 Jun;13(2):155-9. doi: 10.1093/ije/13.2.155.
One hundred consecutive patients with histologically confirmed colorectal cancer and an equal number of age- and sex-matched orthopaedic patients as hospital controls were interviewed about demographic, socioeconomic, biometric and medical variables. Cholecystectomy was significantly more frequent among cases than controls, but there was no side-predilection of the post-cholecystectomy tumours. The frequency of bowel evacuation was significantly higher among cases, particularly those with rectal cancer, an observation which appears contradictory to the 'prolonged bowel transit time--high colorectal cancer risk' hypothesis. No significant differences were found between cases and controls with respect to socioeconomic status, height and weight, smoking habits, use of laxatives and (for females) parity, age at first pregnancy, and age at menopause; however, cases appeared to be younger at menarche.
我们对100例经组织学确诊的结直肠癌患者以及100例年龄和性别匹配的骨科患者（作为医院对照）进行了访谈，询问了他们的人口统计学、社会经济、生物特征和医学变量。病例组胆囊切除术的发生率显著高于对照组，但胆囊切除术后肿瘤无侧别偏好。病例组的排便频率显著更高，尤其是直肠癌患者，这一观察结果似乎与“肠道转运时间延长——结直肠癌风险高”的假说相矛盾。在社会经济地位、身高和体重、吸烟习惯、泻药使用情况以及（女性的）产次、初孕年龄和绝经年龄方面，病例组和对照组之间未发现显著差异；然而，病例组的月经初潮年龄似乎更小。
