Coggle J E, Tarling J D
Cell Tissue Kinet. 1982 Mar;15(2):139-43. doi: 10.1111/j.1365-2184.1982.tb01032.x.
The study of pulmonary alveolar macrophages (PAMs) involves two techniques, one following the migration of a cohort of labelled PAMs from the lung and the other involves the use of a continuous labelling method with [3H]TdR. In both studies, strikingly similar, probably biphasic curves are obtained that can be interpreted as indicating the existence of two proliferating cell populations with turnover times of approximately 10 days and approximately 35 days. It is suggested that one of these compartments is an intra-alveolar PAM population whilst the other probably represents a precursor population. It is also possible to interpret the data as indicating a single, and probably solely intra-alveolar, PAM population with a very skewed distribution of cell cycle times.
对肺泡巨噬细胞（PAM）的研究涉及两种技术，一种是追踪一群标记的PAM从肺中的迁移，另一种是使用[3H]TdR进行连续标记的方法。在这两项研究中，都获得了惊人相似的、可能呈双相的曲线，这些曲线可以解释为表明存在两个增殖细胞群体，其更新时间分别约为10天和约35天。有人认为，其中一个区室是肺泡内PAM群体，而另一个可能代表前体细胞群体。也可以将这些数据解释为表明存在一个单一的、可能仅存在于肺泡内的PAM群体，其细胞周期时间分布非常不均一。
