Durrington P N
Clin Chim Acta. 1982 Mar 26;120(1):21-8. doi: 10.1016/0009-8981(82)90073-0.
The concentration of cholesterol in serum high density lipoproteins (HDL) and their subfractions (HDL2 and HDL3) was determined in men and women with type I diabetes treated with insulin and in non-diabetic men and women matched for age, weight and serum cholesterol, but not for triglyceride-rich lipoproteins which were higher in the diabetic patients. In none of the patients was the diabetes badly controlled as assessed by measurement of the percentage of haemoglobin in the glycosylated state (HbA1). Regardless of their diabetic control, significantly increased serum HDL3 cholesterol concentration was found in male diabetic patients compared to non-diabetic controls, and in both male and female diabetics the ratio of HDL2 to HDL3 cholesterol was significantly reduced. In patients with well-controlled diabetes (HbA1 less than or equal to 9%) serum HDL3 cholesterol was significantly increased in both men and women, whereas in those with less well-controlled diabetes (HbA greater than 9%) it was similar to that of non-diabetic controls. In only one group of patients, the less well controlled men, was there a significant reduction in serum HDL2 cholesterol. On the basis of current theory, the results of this study would support the view that HDL3 does not contribute to the inverse relationship between total serum HDL and the risk of ischaemic heart disease.
测定了接受胰岛素治疗的I型糖尿病男性和女性以及年龄、体重和血清胆固醇相匹配，但富含甘油三酯脂蛋白水平不同（糖尿病患者的该指标更高）的非糖尿病男性和女性血清高密度脂蛋白（HDL）及其亚组分（HDL2和HDL3）中的胆固醇浓度。通过测量糖化状态下血红蛋白的百分比（HbA1）评估，所有患者的糖尿病均未得到严重控制。无论糖尿病控制情况如何，与非糖尿病对照组相比，男性糖尿病患者血清HDL3胆固醇浓度显著升高，且男性和女性糖尿病患者HDL2与HDL3胆固醇的比值均显著降低。在糖尿病控制良好（HbA1小于或等于9%）的患者中，男性和女性的血清HDL3胆固醇均显著升高，而在糖尿病控制较差（HbA大于9%）的患者中，其血清HDL3胆固醇与非糖尿病对照组相似。仅在一组患者（糖尿病控制较差的男性）中，血清HDL2胆固醇有显著降低。根据当前理论，本研究结果支持以下观点：HDL3与血清总HDL和缺血性心脏病风险之间的负相关关系无关。
