Gillberg C, Rasmussen P, Wahlström J
Clin Genet. 1982 Jan;21(1):69-73. doi: 10.1111/j.1399-0004.1982.tb02082.x.
Paediatric and neurodevelopmental examinations were made of 122 children between the ages of 5 and 7 years. The mothers of 62 of these children had undergone amniocentesis for prenatal chromosome determination. The other 60 children were controls, matched for time of birth and maternal age. The fact that no difference between the groups was revealed in respect of paediatric and neurodevelopmental disorders, orthopaedic abnormalities, or respiratory problems during the neonatal period indicates that the risk for developmental complications is not increased in children born after amniocentesis in the second trimester.
对122名5至7岁的儿童进行了儿科和神经发育检查。其中62名儿童的母亲在孕期接受了羊水穿刺以进行产前染色体测定。另外60名儿童为对照组，在出生时间和母亲年龄方面进行了匹配。两组在儿科和神经发育障碍、骨科异常或新生儿期呼吸问题方面未发现差异，这表明孕中期羊水穿刺术后出生的儿童发生发育并发症的风险并未增加。
