关于雌二醇给药对鸡肝脏中某些叶酸代谢酶活性影响的时间进程研究。

Time-course studies on the effects of oestradiol administration on the activity of some folate-metabolizing enzymes in chicken liver.

Burns R A, Jackson N

Comp Biochem Physiol B. 1982;71(3):351-5. doi: 10.1016/0305-0491(82)90394-7.

Abstract

The specific activities of some enzymes of folate metabolism were measured in the liver of folate-treated and folate-deficient immature female chickens at intervals up to 9 days after an initial administration of 17 beta-oestradiol dipropionate. 2. An increase in dihydrofolate reductase activity after 3 days and decreases in 10-formyltetrahydrofolate synthetase and 5,10-methylenetetrahydrofolate dehydrogenase activities after 2 days became evident as a result of oestradiol treatment. 3. After 9 days, oestradiol caused a small decrease in glutamate formiminotransferase activity. 4. In folate-deficient chickens the activity of dihydrofolate reductase was decreased and that of serine hydroxymethyltransferase, 10-formyltetrahydrofolate synthetase and 5,10-methylenetetrahydrofolate dehydrogenase was increased in both non-hormone-treated and oestradiol-treated animals.

摘要

在初次给予二丙酸雌二醇后长达9天的时间内，定期测量经叶酸处理和叶酸缺乏的未成熟雌性鸡肝脏中某些叶酸代谢酶的比活性。2. 雌二醇处理的结果显示，3天后二氢叶酸还原酶活性增加，2天后10-甲酰四氢叶酸合成酶和5,10-亚甲基四氢叶酸脱氢酶活性降低。3. 9天后，雌二醇使谷氨酸亚胺甲基转移酶活性略有降低。4. 在叶酸缺乏的鸡中，无论是否接受激素处理，二氢叶酸还原酶活性均降低，丝氨酸羟甲基转移酶、10-甲酰四氢叶酸合成酶和5,10-亚甲基四氢叶酸脱氢酶活性均增加。