Chmurzyńska W, Manteuffel-Cymborowska M, Sikora E, Grzelakowska-Sztabert B
Cancer Lett. 1984 Dec;25(2):217-24. doi: 10.1016/s0304-3835(84)80048-8.
The activity of 4 enzymes involved in the formation and interconversion of folate coenzymes has been examined in liver and kidney of healthy and Ehrlich ascites carcinoma-bearing mice. In the liver, a 50% increase of methylenetetrahydrofolate reductase activity was shown soon after tumour cell inoculation, while the activity of formyltetrahydrofolate synthetase and methylenetetrahydrofolate dehydrogenase decrease by 20% at an advanced stage of tumour development. In kidneys of the host mouse the only change observed was a decrease of dihydrofolate reductase activity. The levels of activity of all assayed enzymes found in host organs were similar to that in Ehrlich carcinoma cells.
在健康小鼠和携带艾氏腹水癌的小鼠的肝脏和肾脏中，对参与叶酸辅酶形成和相互转化的4种酶的活性进行了检测。在肝脏中，接种肿瘤细胞后不久，亚甲基四氢叶酸还原酶的活性增加了50%，而在肿瘤发展的晚期，甲酰四氢叶酸合成酶和亚甲基四氢叶酸脱氢酶的活性下降了20%。在宿主小鼠的肾脏中，观察到的唯一变化是二氢叶酸还原酶的活性降低。宿主器官中所有检测酶的活性水平与艾氏癌细胞中的相似。
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