Demedts M, Beckers J, Rochette F, Bulcke J
Eur J Respir Dis. 1982 Jan;63(1):62-7.
Pulmonary function studies were carried out in 29 patients with moderate neuromuscular disease who had virtually no respiratory complaints. The earliest and most pronounced abnormalities were decreased transrespiratory pressures. Next a restrictive pulmonary defect with increased residual volume and a proportional decrease of maximal expiratory flows occurred, together with a decrease in static lung compliance. Because of a decrease in transpulmonary pressure at total lung capacity and often an increase in diffusing capacity per unit lung volume the above mentioned restrictive defects were attributed to muscular weakness and interstitial lung disease was excluded. Finally, some ventilation inequality could be found, probably originating in the poorly ventilated supradiaphragmatic regions.
对29例患有中度神经肌肉疾病且几乎没有呼吸方面主诉的患者进行了肺功能研究。最早且最明显的异常是跨呼吸压降低。接下来出现了限制性肺功能缺陷，残气量增加，最大呼气流量成比例下降，同时静态肺顺应性降低。由于肺总量时跨肺压降低，且单位肺容积弥散量常增加，上述限制性缺陷被归因于肌肉无力，排除了间质性肺病。最后，发现了一些通气不均，可能源于膈肌上区域通气不良。
