Kjuus H, Lislerud A, Lyngdal P T, Omland H, Stave O, Langård S
Int Arch Occup Environ Health. 1982 Feb;49(3-4):281-92. doi: 10.1007/BF00377937.
The possible association between selected cancers and polluted work places has been studied in a hospital-based, case-control study. By dividing all jobs in the participants working career into "polluted" and "clean", a crude measure for the total industrial exposure a worker experiences throughout his life was established. Among 103 age-matched, case-control pairs the overall estimated relative risk (RR) for exposed subjects (greater than or equal to 10 years in a polluted work place) of developing cancer compared to nonexposed (less than 10 years in a polluted work place) was 1.1. The only subgroup where a significant difference was found between the cases and the controls was the lung cancer subgroup (RR = 4.0, p = 0.02, two-tailed). When the 30 lung cancer cases were compared to an alternative control group consisting of 60 subjects matched for age and smoking habits, an estimated RR of 4.5 was found. A moderate, but not significant association between lung cancer and definite asbestos exposure was also found (RR: 2.3). As most workers are exposed to a variety of industrial agents throughout their working careers, further development of methods for characterizing combined exposures are needed, both for retrospective and prospective purposes.
在一项基于医院的病例对照研究中，对特定癌症与污染工作场所之间可能存在的关联进行了研究。通过将参与者职业生涯中的所有工作分为“污染性”和“清洁性”工作，建立了一种衡量工人一生中所经历的总体工业暴露的粗略指标。在103对年龄匹配的病例对照中，与未暴露者（在污染工作场所工作少于10年）相比，暴露者（在污染工作场所工作大于或等于10年）患癌的总体估计相对风险（RR）为1.1。病例组和对照组之间唯一存在显著差异的亚组是肺癌亚组（RR = 4.0，p = 0.02，双侧）。当将30例肺癌病例与由60名年龄和吸烟习惯匹配的受试者组成的替代对照组进行比较时，发现估计RR为4.5。还发现肺癌与明确的石棉暴露之间存在中度但不显著的关联（RR：2.3）。由于大多数工人在其整个职业生涯中会接触多种工业制剂，因此需要进一步开发用于表征联合暴露的方法，以用于回顾性和前瞻性研究。
