Scholtens R, Scholten J, de Koning H W, Tijssen J, ten Hoopen H W, Olthuis F M, Feijen J
Int J Artif Organs. 1982 Jan;5(1):33-6.
Patients suffering from primary hyperoxaluria show elevated plasma concentrations of oxalic acid and glyoxylic acid. The in vitro adsorption of these compounds into activated charcoal, a series of neutral and ion exchange resins and onto hydrous zirconium oxide has been investigated. Hydrous zirconium oxide was the most effective sorbent studied for the removal of both oxalic acid and glyoxylic acid. In batch experiments, the zirconium oxide was capable of binding 5.5 mu mol oxalic acid and 8 mu mol glyoxylic acid per gram sorbent using 0.5 gram sorbent and 50 ml of solutions with initial concentrations of 100 mu mol . L-1 and an ionic composition resembling that of plasma. Recirculation of 2 L of the same solutions through 12 gram of a mixture of hydrous zirconium oxide and alumina for 6 hours at a flow rate of 12 ml . min-1, resulted in a final concentration of 70 mu mol . L-1 of oxalic acid and 50 mu mol . L-/ of glyoxylic acid.
患有原发性高草酸尿症的患者血浆中草酸和乙醛酸的浓度会升高。已对这些化合物在体外被活性炭、一系列中性和离子交换树脂以及水合氧化锆吸附的情况进行了研究。水合氧化锆是所研究的用于去除草酸和乙醛酸的最有效吸附剂。在批量实验中，使用0.5克吸附剂和50毫升初始浓度为100微摩尔·升⁻¹且离子组成类似于血浆的溶液，氧化锆每克吸附剂能够结合5.5微摩尔草酸和8微摩尔乙醛酸。以12毫升·分钟⁻¹的流速将2升相同溶液通过12克水合氧化锆和氧化铝的混合物循环6小时，最终草酸浓度为70微摩尔·升⁻¹，乙醛酸浓度为50微摩尔·升⁻¹。
