Paul B S, Parrish J A
J Invest Dermatol. 1982 May;78(5):371-4. doi: 10.1111/1523-1747.ep12507481.
A study was done to demonstrate quantitatively and graphically the way in which suberythemogenic doses of broadband UVA and UVB interact in producing a visible erythema. On the backs of fair-skinned human volunteers the minimal erythema dose (MED) was determined for polychromatic UVA and UVB. Increasing fractions of the UVA MED were given to sites already exposed to various fractions of the UVB MED resulting in sites exposed to various doses of both UVA and UVB. The same experiment was repeated with the order of wavebands reversed. It was demonstrated that when UVA was followed by UVB an erythema was produced in those sites where the sum of the fractions was equal to one, an interaction termed photoaddition. When the UVA exposure followed the UVB, erythema was again predominantly noted in those sites demonstrating photoaddition. However, in the latter case, numerous sites of threshold erythema were noted where the sum of the fractions was greater than one. This is suggestive of photorecovery. No evidence of photoaugmentation was observed with either order of exposure.
开展了一项研究，以定量和图示方式展示亚致红斑剂量的宽带紫外线A（UVA）和紫外线B（UVB）在产生可见红斑过程中的相互作用方式。在皮肤白皙的人类志愿者背部，测定了多色UVA和UVB的最小红斑剂量（MED）。将递增比例的UVA MED给予已暴露于不同比例UVB MED的部位，从而使这些部位暴露于不同剂量的UVA和UVB。以相反的波段顺序重复相同实验。结果表明，当UVA在UVB之后时，在各部分总和等于1的部位会产生红斑，这种相互作用称为光加成。当UVA暴露在UVB之后时，在显示光加成的部位再次主要观察到红斑。然而，在后一种情况下，在各部分总和大于1的部位发现了许多阈红斑部位。这提示了光恢复。无论暴露顺序如何，均未观察到光增强的证据。
