Boer J, Schothorst A A, Suurmond D
J Invest Dermatol. 1981 Jan;76(1):56-8. doi: 10.1111/1523-1747.ep12524880.
The effect of repeated exposure to an additive dose of long ultraviolet (UVA) radiation on the erythemogenic and therapeutic effects of middle ultraviolet (UVB) irradiation was investigated in 8 patients with psoriasis. The surface of the backs of these patients was divided into 2 parts, 1 of which received only UVB irradiation 4 times a week and the other UVA + UVB. UVB was provided by Philips TL-12 lamps and UVA by glass-filtered Philips TL-09 lamps. UVA was held constantly at 10 J/cm2, whereas UVB was increased. The erythemogenic effects of UVA + UVB and UVB alone were evaluated by 4 tests during the treatment to determine the minimal erythema dose (MED). Test I (at the start of the therapy) showed a photoaugmentative effect which was no longer apparent in test III (third week). Test III showed a reversal of the ratios of the MEDs of the sites irradiated with UVA + UVB and UVB (MED A + B/MED B). This is ascribed to the marked pigmentation which appeared after repeated irradiation with the UVA + UVB combination. Comparison showed for the improvement of the psoriasis no distinct differences between UVA + UVB irradiation and UVB alone, but the former had the cosmetic advantage of giving pleasing tan.
在8例银屑病患者中，研究了重复暴露于递增剂量的长波紫外线（UVA）辐射对中波紫外线（UVB）照射的致红斑和治疗效果的影响。这些患者背部皮肤表面被分为两部分，其中一部分每周接受4次UVB单独照射，另一部分接受UVA + UVB照射。UVB由飞利浦TL - 12灯提供，UVA由玻璃滤过的飞利浦TL - 09灯提供。UVA剂量恒定为10 J/cm²，而UVB剂量递增。在治疗期间通过4次测试评估UVA + UVB和单独UVB的致红斑效果，以确定最小红斑量（MED）。测试I（治疗开始时）显示出光增强效应，而在测试III（第三周）时这种效应不再明显。测试III显示接受UVA + UVB和UVB照射部位的MED比值发生了逆转（MED A + B/MED B）。这归因于UVA + UVB联合重复照射后出现的明显色素沉着。比较结果显示，UVA + UVB照射和单独UVB照射在银屑病改善方面无明显差异，但前者具有能产生令人愉悦晒黑效果的美容优势。
