Barth A, Zaumseil J, Klinger W
Acta Biol Med Ger. 1978;37(1):147-54.
Bile flow and excretion of monohydroxy-, dihydroxy- and trihydroxy-bile acids (MBA, DBA and TBA) were estimated after acute and subacute phenobarbital and chlorpromazine pretreatment in 60-day-old male Wistar rats. Bile was collected in bile-fistula rats in three 1-hour periods. MBA were not detected. Neither single nor repeated ip. administration of different amounts of saline before bile sampling nor oral water supply within the bile collection period influenced the bile flow and excretion of DBA and TBA. Phenobarbital administration (60 mg/kg b.w. ip.) 2 hrs before bile sampling did not influence bile flow and bile acid (BA) excretion. After 3 days pretreatment with phenobarbital (3 X 60 mg/kg b.w. ip.) the bile flow was somewhat increased, BA-excretion was unchanged and the relation TBA/DBA diminished. Chlorpromazine administration (40 mg/kg b.w. ip.) 1,5 hrs before bile sampling decreased bile flow and BA excretion within the first collection period, whereas bile flow and BA excretion increased in the thrid collection period. No signs of cholestasis were observed after chlorpromazine pretreatment once a day for 3 days. Bile flow and BA excretion were increased and the relation TBA/DBA was unchanged.
在对60日龄雄性Wistar大鼠进行急性和亚急性苯巴比妥及氯丙嗪预处理后，评估胆汁流量以及单羟基、二羟基和三羟基胆汁酸（MBA、DBA和TBA）的排泄情况。通过胆汁瘘管大鼠在三个1小时时间段内收集胆汁。未检测到MBA。在胆汁采样前单次或重复腹腔注射不同剂量的生理盐水，以及在胆汁收集期间口服供水，均未影响胆汁流量以及DBA和TBA的排泄。在胆汁采样前2小时腹腔注射苯巴比妥（60 mg/kg体重），未影响胆汁流量和胆汁酸（BA）排泄。在苯巴比妥预处理3天（3×60 mg/kg体重腹腔注射）后，胆汁流量有所增加，BA排泄未改变，且TBA/DBA比值降低。在胆汁采样前1.5小时腹腔注射氯丙嗪（40 mg/kg体重），在第一个收集时间段内胆汁流量和BA排泄减少，而在第三个收集时间段内胆汁流量和BA排泄增加。氯丙嗪每天预处理1次，连续3天，未观察到胆汁淤积迹象。胆汁流量和BA排泄增加，且TBA/DBA比值未改变。
