Bergmann R, Barth A, Zaumseil J, Klinger W
Acta Biol Med Ger. 1979;38(8):1193-200.
The influence of metyrapone on bile flow and excretion of mono-(MBA), di-(DBA) and trihydroxy-(TBA)-bile acids was investigated in adult male Wistar rats after single and repeated pretreatment. MBA were not found in the rat bile. Metyrapone administration (200 mg/kg b.w. i.p.) 1 h before onset of a 3-hour bile collection period diminished bile flow and excretion of DBA and TBA. The relation TBA/DBA was changed towards DBA. Similar results were found after repeated administration 12 h after the last metyrapone injection (4 x 50 mg/kg b.w. i.p. per day for 4 consecutive days). But 60 h after the last metyrapone administration bile flow and the excretion of TBA were enhanced and the TBA/DBA ratio was changed towards TBA. The possible influence of metyrapone on bile acid hydroxylation is discussed and compared with metyrapone action on hydroxylation of foreign compounds.
在成年雄性Wistar大鼠单次和重复预处理后，研究了美替拉酮对胆汁流量以及单羟基胆汁酸（MBA）、二羟基胆汁酸（DBA）和三羟基胆汁酸（TBA）排泄的影响。在大鼠胆汁中未发现MBA。在3小时胆汁收集期开始前1小时腹腔注射美替拉酮（200 mg/kg体重），可减少胆汁流量以及DBA和TBA的排泄。TBA/DBA的关系向有利于DBA的方向变化。在最后一次注射美替拉酮（连续4天，每天4次，每次50 mg/kg体重腹腔注射）12小时后重复给药，得到了类似的结果。但在最后一次注射美替拉酮60小时后，胆汁流量和TBA排泄增加，TBA/DBA比值向有利于TBA的方向变化。本文讨论了美替拉酮对胆汁酸羟基化的可能影响，并与美替拉酮对外源化合物羟基化的作用进行了比较。
