Barth A, Zaumseil J, Klinger W
Acta Biol Med Ger. 1978;37(10):1615-22.
Bile flow and excretion of monohydroxy-, dihydroxy- and trihydroxy bile acids (MBA, DBA and TBA) were estimated after acute and subacute progesterone and phenylbutazone pretreatment in adult male Wistar rats in three one-hour periods. Different pretreatment with sunflower oil did not influence bile flow and excretion of DBA and TBA. MBA were not detected. Different administration of progesterone and phenylbutazone did not significantly change the TBA/DBA ratio. Progesterone administration (50 mg/kg b. w. i. p.) 2 hours before bile sampling increased bile flow and bile acid excretion in the third one-hour period. After 3 days of pretreatment with progesterone (3 X 50 mg/kg b. w. i. p.) bile flow and TBA-excretion were diminished. Phenylbutazone (100 mg/kg b. w. i. p.) increased bile flow and TBA-excretion both after acute and subacute administration.
在成年雄性Wistar大鼠中，在三个一小时时间段内对其进行急性和亚急性孕酮及保泰松预处理后，估计胆汁流量以及单羟基、二羟基和三羟基胆汁酸（MBA、DBA和TBA）的排泄情况。用向日葵油进行不同的预处理对胆汁流量以及DBA和TBA的排泄没有影响。未检测到MBA。孕酮和保泰松的不同给药方式并未显著改变TBA/DBA比值。在胆汁采样前2小时给予孕酮（50毫克/千克体重，腹腔注射）可使第三个一小时时间段内的胆汁流量和胆汁酸排泄增加。在用孕酮进行3天预处理（3×50毫克/千克体重，腹腔注射）后，胆汁流量和TBA排泄减少。保泰松（100毫克/千克体重，腹腔注射）在急性和亚急性给药后均增加了胆汁流量和TBA排泄。
