Zimmermann T, Hummel L
Acta Biol Med Ger. 1978;37(2):223-7.
The fatty acid synthesis as measured by in vitro incorporation of 1-[14C]-acetate and 3H2O into maternal and fetal tissues of the rat has been quantitatively determined. The results showed that because of the endogenous dilution the incorporation of [14C]-acetate does not provide a quantitative measure of fatty acid synthesis. The incorporation of tritium per g of tissue into the fatty acid fraction of maternal and fetal liver (day 21 of pregnancy) was found to be 260 and 130 nmoles per g per min, respectively. The incorporation was lesser in liver of female non-pregnant rats (31 nmoles per g per min) and placenta (4.0 nmoles per g per min). The calculated rates of synthesis of fatty acids were used to support the following views: At the end of gestation about 25% of all fatty acids synthesized within the fetus arise from fetal liver. From day 15 to 21 of pregnancy the fetal fatty acid synthesis supplies about half of the amount of fatty acids which are accumulated due to growth.
通过体外将1-[¹⁴C]-乙酸盐和³H₂O掺入大鼠母体和胎儿组织中来测定脂肪酸合成，已进行了定量测定。结果表明，由于内源性稀释，[¹⁴C]-乙酸盐的掺入并不能提供脂肪酸合成的定量测量。发现每克组织中氚掺入妊娠第21天母体和胎儿肝脏脂肪酸部分的量分别为每克每分钟260和130纳摩尔。未怀孕雌性大鼠肝脏（每克每分钟31纳摩尔）和胎盘（每克每分钟4.0纳摩尔）中的掺入量较少。计算出的脂肪酸合成速率用于支持以下观点：在妊娠末期，胎儿体内合成的所有脂肪酸中约25%来自胎儿肝脏。从妊娠第15天到21天，胎儿脂肪酸合成提供了因生长而积累的脂肪酸量的约一半。
