Bundey S, Evans K
J Med Genet. 1982 Feb;19(1):16-21. doi: 10.1136/jmg.19.1.16.
The main purpose of this study was to see if the offspring of surviving neuroblastoma, ganglioneuroblastoma, or ganglioneuroma patients have themselves a risk for developing tumours. No such risk was found. There was a total of 45 liveborn children who were all healthy. These children have passed through about 37 lifetimes of risk for developing neuroblastoma and about six lifetimes of risk for developing ganglioneuroma. No excess of cancers was found among parents and sibs. It was interesting that there was a large female excess (35:12) among these survivors. One factor which may give rise to a better prognosis in females is the tendency of their tumours to mature to benign forms.
本研究的主要目的是观察神经母细胞瘤、神经节神经母细胞瘤或神经节神经瘤存活患者的后代自身是否有患肿瘤的风险。未发现此类风险。共有45名活产儿童，他们都很健康。这些儿童已经历了约37个患神经母细胞瘤的风险期和约6个患神经节神经瘤的风险期。在父母和兄弟姐妹中未发现癌症增多的情况。有趣的是，这些幸存者中女性比例过高（35:12）。女性预后较好的一个因素可能是其肿瘤倾向于成熟为良性形式。
