Robertson C M, Tyrrell J C, Pritchard J
Department of Haematology and Oncology, Hospital for Sick Children, London, United Kingdom.
Eur J Pediatr. 1991 Sep;150(11):789-92. doi: 10.1007/BF02026713.
It is known that some cases of neural crest tumours are hereditary. We report the clinical and cytogenetic findings in a three-generation, extended family, four members of which developed single or multiple neural crest tumours (ganglioneuroma, ganglioneuroblastoma or neuroblastoma). To our knowledge, this is the first report of a family with three generations affected. No constitutional cytogenetic abnormality was found in the two members tested. We also review the literature on familial neural crest tumours, with emphasis on those affecting more than one generation. It is important that a detailed family history, with particular reference to tumours, is obtained in all cases of childhood cancer.
已知某些神经嵴肿瘤病例具有遗传性。我们报告了一个三代大家庭的临床和细胞遗传学研究结果，该家庭中有四名成员患了单个或多个神经嵴肿瘤（神经节瘤、神经节神经母细胞瘤或神经母细胞瘤）。据我们所知，这是首例三代人都受影响的家庭报告。在接受检测的两名家庭成员中未发现染色体异常。我们还回顾了关于家族性神经嵴肿瘤的文献，重点关注那些影响不止一代人的病例。对于所有儿童癌症病例，获取详细的家族病史，尤其是关于肿瘤的病史，是很重要的。
