Yamamoto Y, Satoh K, Unno R, Miyazaki R
Jpn J Antibiot. 1982 Jan;35(1):273-80.
Daily 150 mg or 200 mg dose of netilmicin (NTL) were administered to 26 patients with chronic complicated urinary tract infections for 5 days, and the following results were obtained. 1) Out of 26 cases excellent response was seen in 5 cases, good response in 4, and poor response in 11. Effectiveness rate was 45%. Six cases were excluded from the evaluation. 2) Effective result was not seen in the catheterized group, whereas 5 excellent and 4 good cases were observed in the noncatheterized group, resulting 60% in effectiveness rate. 3) MICs of NTL against various bacteria were comparative to GM against P. aeruginosa, to AMK against Serratia, and to both GM and AMK against other bacteria. 4) Except a slight local irritation, no subjective side effect was observed. One case showed a slight elevation in hepatic function tests but it was not definitely judged as the side effect due to NTL.
对26例慢性复杂性尿路感染患者每日给予150毫克或200毫克的奈替米星（NTL），持续用药5天，获得以下结果。1）26例中，5例显效，4例有效，11例疗效不佳。有效率为45%。6例被排除在评估之外。2）导尿组未见有效结果，而非导尿组有5例显效和4例有效，有效率为60%。3）NTL对各种细菌的最低抑菌浓度（MIC）与庆大霉素（GM）对铜绿假单胞菌的MIC、与阿米卡星（AMK）对沙雷菌的MIC相当，对其他细菌的MIC与GM和AMK均相当。4）除有轻微的局部刺激外，未观察到主观副作用。1例肝功能检查结果略有升高，但不能明确判定为NTL所致的副作用。
