Saito I
Jpn J Antibiot. 1982 Aug;35(8):1925-33.
Netilmicin was administered to 1 case of simple acute pyelonephritis and 21 cases of complicated urinary tract infections, 22 cases in total, and the effects were evaluated clinically. Total clinical effects of netilmicin evaluated by the UTI standard for evaluation of drug effects showed 61.9% of clinical effectiveness in 21 cases, and the results are satisfactory because 11 cases out of 21 cases were catheterized. The result was examined bacteriologically; the frequency of detection of particular strains among 23 strains clinically isolated from complicated urinary tract infections was that 10 strains of P. aeruginosa (43.5%), 3 of S. marcescens (13.0%), and 3 of E. coli (13.0%), and the ratios of bacteriologically disappeared strains were 70%, 33.3% and 66.7%, respectively, and the overall disappearance ratio was 73.9%. The MIC's determined for 17 strains and disappearance of the bacteria were examined; when MIC was less than 6.25 mcg/ml, 10 strains out of 12 disappeared, that is, 83% of disappearance was obtained. When MIC was larger than 100 mcg/ml, 2 strains out of 5 disappeared, that is, 40% of disappearance was obtained. Disappeared 2 strains of bacteria were isolated from patients who were not catheterized. Neither subjective symptoms nor abnormal laboratory findings related to the drug were observed. It may be said from these findings that netilmicin is an effective drug for urinary tract infections.
将奈替米星用于1例单纯性急性肾盂肾炎和21例复杂性尿路感染患者，共22例，进行临床疗效评估。根据UTI药物疗效评估标准对奈替米星的总体临床疗效进行评估，结果显示21例患者中有61.9%临床有效，鉴于21例患者中有11例曾留置导尿管，该结果令人满意。对结果进行了细菌学检查；从复杂性尿路感染患者临床分离出的23株菌株中，特定菌株的检出频率为：铜绿假单胞菌10株（43.5%）、粘质沙雷氏菌3株（13.0%）、大肠杆菌3株（13.0%），细菌学转阴率分别为70%、33.3%和66.7%，总体转阴率为73.9%。测定了17株菌株的最低抑菌浓度（MIC）并检查了细菌转阴情况；当MIC小于6.25 mcg/ml时，12株中有10株转阴，即转阴率为83%。当MIC大于100 mcg/ml时，5株中有2株转阴，即转阴率为40%。有2株转阴的细菌是从未留置导尿管的患者中分离出来的。未观察到与药物相关的主观症状或实验室检查异常。从这些结果可以看出，奈替米星是治疗尿路感染的有效药物。
