Shindo K, Kosaki G
Jpn J Surg. 1982;12(1):41-5. doi: 10.1007/BF02469014.
Chronic renal failure was induced in rats by a five-sixths nephrectomy, after which incisional wounds were made in the abdominal skin, aponeurosis of linea alba, stomach and colon. Bursting strength of the colon and tensile strength of the skin, aponeurosis and stomach were usually lower in the uremics than in the controls, but there was no statistical significance except for colonic wounds on the 7th and 10th postoperative days. Before these results can be extrapolated to clinical cases, pre- and post-surgical treatment must be considered, because immunosuppressants, anticoagulants, and other compounds may influence the retardation of wound healing.
通过切除六分之五的肾脏诱导大鼠发生慢性肾衰竭，之后在腹部皮肤、白线腱膜、胃和结肠制造切口创伤。尿毒症大鼠结肠的抗破裂强度以及皮肤、腱膜和胃的抗张强度通常低于对照组，但除了术后第7天和第10天的结肠伤口外，差异无统计学意义。在将这些结果外推至临床病例之前，必须考虑手术前后的治疗，因为免疫抑制剂、抗凝剂和其他化合物可能会影响伤口愈合的延迟。
