Shindo K, Kosaki G
Jpn J Surg. 1982;12(1):46-51. doi: 10.1007/BF02469015.
Incisional wounds of the abdominal skin, aponeurosis, stomach and colon were investigated microscopically for a comparison of the findings between uremic and normal rats. The grade of edema and number of inflammatory cells were increased in the rats with uremia and the granulation zone was also larger in the uremics. Hydroxyproline was assayed in the wound tissues by a modification of the technique of Stegemann and Stalder. The hydroxyproline level was lower in the uremics (p less than 0.05) only in the aponeurosis of the 5th postoperative day and in the colon of the 3.5th to 7th day. The correlation coefficient calculated for the blood urea level, biomechanical strength and hydroxyproline level was nil. If these results can validly be extrapolated to patients with chronic renal failure, careful management and avoidance of possible wound infections is of the greatest importance for surgical patients.
对腹部皮肤、腱膜、胃和结肠的切口伤口进行显微镜检查，以比较尿毒症大鼠和正常大鼠的检查结果。尿毒症大鼠的水肿程度和炎症细胞数量增加，且肉芽组织区也更大。通过对施特格曼和施塔尔德技术的改进，对伤口组织中的羟脯氨酸进行了测定。仅在术后第5天的腱膜以及第3.5天至第7天的结肠中，尿毒症大鼠的羟脯氨酸水平较低（p小于0.05）。计算得出的血尿素水平、生物力学强度和羟脯氨酸水平之间的相关系数为零。如果这些结果能够有效地外推至慢性肾衰竭患者，那么对于外科手术患者而言，谨慎管理并避免可能的伤口感染至关重要。
