Rouveix B
Nouv Presse Med. 1982 Mar 6;11(11):843-6.
The author has designed a new quantitative leucocyte aggregation test a measure cell-mediated immunity in man. The test involves continuous recording of light absorbance by stirred leucocyte suspensions. Potentially, measurement of direct leucocyte aggregation offers considerable advantages in terms of sensitivity, reproducibility and simplicity of execution. The technique was initially developed in animals and made it possible to assay very small amounts of lymphokines. The results obtained in man with antigenic drugs, such as penicillin, confirm that the aggregation test is much more sensitive than the migration inhibition test. Its precise significance remains uncertain, but it already promises to constitute a simple and highly reliable means of diagnosing and preventing drug hypersensitivity.
作者设计了一种新的定量白细胞聚集试验，用于测量人体的细胞介导免疫。该试验包括通过搅拌白细胞悬液连续记录吸光度。就敏感性、可重复性和操作简便性而言，直接测量白细胞聚集具有相当大的优势。该技术最初是在动物身上开发的，使得能够检测极少量的淋巴因子。在人体中使用抗原性药物（如青霉素）获得的结果证实，聚集试验比迁移抑制试验更敏感。其确切意义尚不确定，但它已有望成为诊断和预防药物超敏反应的一种简单且高度可靠的方法。
