Honglso J K, Alfheim I
Acta Pharmacol Toxicol (Copenh). 1978 Sep;43(3):246-50. doi: 10.1111/j.1600-0773.1978.tb02261.x.
Renewal of growth medium caused an induction of ornithine decarboxylase (ODC) activity in LS cells grown in suspension culture. Addition of low concentrations of fluoride ions to the growth medium (up to 1.3 mM) resulted in a further increase in this induction of ODC-activity, whereas addition of 6 mM fluoride caused an inhibition of the induction and resulted in reduced ODC-activity as compared to controls. Since sodium fluoride had no stimulatory or inhibitory effect on the ODC-activity assay, it is likely that the effect is exerted on the regulation of ODC-activity in the cells. The effect of fluoride ions on the induction of ODC-activity upon renewal of the growth medium was markedly less pronounced in fluoride resistant LS cells.
更换生长培养基会诱导悬浮培养的LS细胞中的鸟氨酸脱羧酶（ODC）活性。向生长培养基中添加低浓度的氟离子（高达1.3 mM）会导致ODC活性的这种诱导进一步增加，而添加6 mM氟则会抑制诱导并导致与对照相比ODC活性降低。由于氟化钠对ODC活性测定没有刺激或抑制作用，因此这种作用可能是对细胞中ODC活性的调节产生的。在耐氟的LS细胞中，氟离子对更换生长培养基后ODC活性诱导的影响明显不那么显著。
