正常及耐氟LS细胞的鸟氨酸脱羧酶活性和多胺含量
Ornithine decarboxylase activity and polyamine content of normal and fluoride resistant LS cells.
作者信息
Hongslo J K
出版信息
Acta Pharmacol Toxicol (Copenh). 1979 Jul;45(1):32-5. doi: 10.1111/j.1600-0773.1979.tb02356.x.
Abstract
The activity of ornithine decarboxylase (ODC) in suspension cultures of mouse fibroblasts, LS cells, varied in a characteristic cyclic pattern after dilution of the cultures. Two strains of fluoride resistant LS cells, FR6 and LSFR6 cells, exhibited the same cyclic pattern, but with markedly higher ODC activities. These fluoride resistant cells, however, contained less putrescine, the product of the ODC reaction. Possible reasons for this finding are discussed.
摘要
在小鼠成纤维细胞LS细胞的悬浮培养物中，鸟氨酸脱羧酶（ODC）的活性在培养物稀释后呈特征性的周期性模式变化。两株耐氟LS细胞FR6和LSFR6细胞表现出相同的周期性模式，但ODC活性明显更高。然而，这些耐氟细胞中的腐胺（ODC反应的产物）含量较少。文中讨论了这一发现的可能原因。
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