Hongslo J K, Holland R I
Acta Pharmacol Toxicol (Copenh). 1979 May;44(5):350-3. doi: 10.1111/j.1600-0773.1979.tb02343.x.
Sodium fluoride exhibited a dose dependent inhibitory effect on protein and DNA synthesis at concentrations from 1.3 mM in growing LS cells. The activity of ornithine decarboxylase (ODC) was slightly stimulated by 0.5 mM-NAF, but inhibited at 1.3 mM and above. The reduced enzyme activity seemed to be due to a reduced de novo formation of the enzyme caused by an inhibition of the protein synthesis. In spite of a reduction of ODC-activity, fluoride had no effect on the cellular polyamine content during the experimental period (10 hours).
在生长的LS细胞中，氟化钠在浓度为1.3 mM时对蛋白质和DNA合成表现出剂量依赖性抑制作用。0.5 mM的氟化钠略微刺激了鸟氨酸脱羧酶（ODC）的活性，但在1.3 mM及以上浓度时则受到抑制。酶活性的降低似乎是由于蛋白质合成受到抑制导致酶的从头合成减少所致。尽管ODC活性降低，但在实验期间（10小时）氟化物对细胞多胺含量没有影响。
