Young E J, Fainstein V, Musher D M
Rev Infect Dis. 1982 Jan-Feb;4(1):69-77. doi: 10.1093/clinids/4.1.69.
This study involved cases of unexplained fever for which an infectious disease consultation was requested and for which an untoward drug reaction was thought responsible. Twelve cases that met strict criteria for drug-induced fever are presented. Antimicrobial agents were responsible for eight cases; other causes included antihypertensive and anticonvulsant drugs and allopurinol. The duration of drug administration before fever appeared was highly variable. Most patients had no history of previous drug reaction. Seven patients had fever with on other symptoms or signs that would suggest a diagnosis of drug-induced fever. Consultations are generally not requested for adverse drug reactions with more typical findings, such as skin rashes and eosinophilia; therefore, the true incidence of drug-induced fever is probably greater than indicated by the 12 definite cases seen in this general hospital during a six-year period.
本研究涉及因不明原因发热而请求感染病会诊且被认为是药物不良反应所致的病例。现报告12例符合药物性发热严格标准的病例。抗菌药物导致了8例；其他病因包括抗高血压药、抗惊厥药和别嘌醇。发热出现前的用药持续时间差异很大。大多数患者既往无药物不良反应史。7例患者发热时无其他提示药物性发热诊断的症状或体征。对于皮疹和嗜酸性粒细胞增多等更典型表现的药物不良反应，通常不会请求会诊；因此，药物性发热的实际发生率可能高于这家综合医院在六年期间所见到的12例确诊病例所显示的发生率。
