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选择性的、纳洛酮可逆的吗啡对习得性行为和海马反应的抑制作用。

Selective, naloxone-reversible morphine depression of learned behavioral and hippocampal responses.

作者信息

Mauk M D, Warren J T, Thompson R F

出版信息

Science. 1982 Apr 23;216(4544):434-6. doi: 10.1126/science.7071592.

DOI:10.1126/science.7071592
PMID:7071592
Abstract

Morphine administered intravenously causes immediate and complete abolition of a simple learned response (classically conditioned nictitating membrane extension in rabbit) and of the associated learning-induced increase in hippocampal neuron activity. Both effects are completely reversed by low doses of naloxone. Morphine has no effect at all on behavioral performance of the unconditioned reflex response.

摘要

静脉注射吗啡会立即并完全消除一种简单的习得反应（兔经典条件反射性瞬膜伸展）以及相关的学习诱导的海马神经元活动增加。低剂量纳洛酮可完全逆转这两种效应。吗啡对非条件反射反应的行为表现完全没有影响。

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Science. 1982 Apr 23;216(4544):434-6. doi: 10.1126/science.7071592.
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