Disopyramide hepatotoxicity and disseminated intravascular coagulation.

A 55-year-old white woman had severe hepatocellular damage after taking disopyramide. Simultaneously, disseminated intravascular coagulation developed with thrombocytopenia, prolonged prothrombin time, and elevated fibrin split products. Both problems gradually subsided 14 days after cessation of disopyramide therapy. This case report shows that disopyramide can have the serious side effect of hepatocellular toxicity and provides evidence of the association of hepatocellular damage and disseminated intravascular coagulation.