人类白细胞抗原与酒精性肝硬化
HLA and alcoholic cirrhosis.
作者信息
Tait B D, Mackay I R
出版信息
Tissue Antigens. 1982 Jan;19(1):6-10. doi: 10.1111/j.1399-0039.1982.tb01410.x.
Abstract
In fifty-seven patients with alcoholic cirrhosis the frequency of HLA-DR2 was found to be 47.4%, in contrast to 26.1% in 119 normal subjects and 14.0% in 43 cases of autoimmune-type chronic active hepatitis (CAH). The frequencies of HLA-DR3 in the three respective groups also differed, being 24.6%, 31.9% and 74.4%. The greatly differing HLA-DR profiles in alcoholic cirrhosis and CAH point to immunogenetic differences in predisposition to these two liver diseases.
摘要
在57例酒精性肝硬化患者中，发现HLA - DR2的频率为47.4%，相比之下，119名正常受试者中该频率为26.1%，43例自身免疫型慢性活动性肝炎（CAH）患者中为14.0%。三组中HLA - DR3的频率也有所不同，分别为24.6%、31.9%和74.4%。酒精性肝硬化和CAH中HLA - DR谱的巨大差异表明这两种肝脏疾病易感性存在免疫遗传学差异。
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