生育酚缺乏对正常和高胆固醇饮食的自发性高血压大鼠动脉壁脂质代谢的影响。
Effect of tocopherol deficiency on lipid metabolism in arterial wall of spontaneously hypertensive rats on normal and high cholesterol diets.
作者信息
Murano S, Shirai K, Matsuoka N, Morisaki N, Sasaki N, Shinomiya M, Mizobuchi M, Saito Y, Kumagai A
出版信息
Tohoku J Exp Med. 1982 Jan;136(1):29-34. doi: 10.1620/tjem.136.29.
Lipid metabolism in the arterial wall of spontaneously hypertensive rats (SHR) fed on tocopherol-deficient diet, high-cholesterol diet or both was studied. Serum tocopherol was greatly decreased in tocopherol-deficient SHR. Lipoperoxide, determined as thiobarbituric acid-reactive substances, was higher in tocopherol-deficient SHR than in normal SHR. Tocopherol-deficient SHR showed a decrease in acid cholesterol esterase activity, but no change in neutral cholesterol esterase, acid and neutral lipase, acyl CoA synthetase, cytidine-diphosphate choline-1-2-diacyl glycerol choline phosphotransferase (CPT) or triglyceride synthesizing activity.
研究了喂食缺乏生育酚饮食、高胆固醇饮食或两者兼有的自发性高血压大鼠（SHR）动脉壁中的脂质代谢。缺乏生育酚的SHR血清生育酚大幅降低。以硫代巴比妥酸反应性物质测定的脂质过氧化物，在缺乏生育酚的SHR中高于正常SHR。缺乏生育酚的SHR酸性胆固醇酯酶活性降低，但中性胆固醇酯酶、酸性和中性脂肪酶、酰基辅酶A合成酶、胞苷二磷酸胆碱-1-2-二酰甘油胆碱磷酸转移酶（CPT）或甘油三酯合成活性没有变化。
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