Murano S, Shirai K, Matsuoka N, Morisaki N, Sasaki N, Shinomiya M, Mizobuchi M, Saito Y, Kumagai A
Tohoku J Exp Med. 1982 Jan;136(1):29-34. doi: 10.1620/tjem.136.29.
Lipid metabolism in the arterial wall of spontaneously hypertensive rats (SHR) fed on tocopherol-deficient diet, high-cholesterol diet or both was studied. Serum tocopherol was greatly decreased in tocopherol-deficient SHR. Lipoperoxide, determined as thiobarbituric acid-reactive substances, was higher in tocopherol-deficient SHR than in normal SHR. Tocopherol-deficient SHR showed a decrease in acid cholesterol esterase activity, but no change in neutral cholesterol esterase, acid and neutral lipase, acyl CoA synthetase, cytidine-diphosphate choline-1-2-diacyl glycerol choline phosphotransferase (CPT) or triglyceride synthesizing activity.
研究了喂食缺乏生育酚饮食、高胆固醇饮食或两者兼有的自发性高血压大鼠（SHR）动脉壁中的脂质代谢。缺乏生育酚的SHR血清生育酚大幅降低。以硫代巴比妥酸反应性物质测定的脂质过氧化物，在缺乏生育酚的SHR中高于正常SHR。缺乏生育酚的SHR酸性胆固醇酯酶活性降低，但中性胆固醇酯酶、酸性和中性脂肪酶、酰基辅酶A合成酶、胞苷二磷酸胆碱-1-2-二酰甘油胆碱磷酸转移酶（CPT）或甘油三酯合成活性没有变化。
