Goto K, Sasano N, Matoba N
Tohoku J Exp Med. 1982 Mar;136(3):285-90. doi: 10.1620/tjem.136.285.
Morphological and functional properties of dispersed cells of human adenomatous goiter and those of the thyroid tissue adjacent to and distant from the nodular lesion (normal control) were investigated. In the presence of TSH, reconstructive arrangement of adenomatous goiter cells into a three-dimensional follicular structure occurred in a similar manner to that of normal controls. An addition of thyrotropin (TSH) to culture resulted in the secretion of thyroid hormones in control cells, but adenomatous goiter cells showed no response to TSH. It was found that the ratio of rT3, T3, the ratio of an inactive to an active form, was about three times higher in adenomatous goiter than in normal control. These findings suggested that conversion from T4 to rT3 is increased in adenomatous goiter.
对人腺瘤性甲状腺肿的分散细胞以及与结节性病变相邻和远离的甲状腺组织（正常对照）的形态学和功能特性进行了研究。在促甲状腺激素（TSH）存在的情况下，腺瘤性甲状腺肿细胞重建为三维滤泡结构的方式与正常对照相似。向培养物中添加促甲状腺素（TSH）会导致对照细胞分泌甲状腺激素，但腺瘤性甲状腺肿细胞对TSH无反应。研究发现，腺瘤性甲状腺肿中反三碘甲腺原氨酸（rT3）与三碘甲腺原氨酸（T3）的比例，即无活性形式与活性形式的比例，比正常对照高约三倍。这些发现表明，腺瘤性甲状腺肿中从T4向rT3的转化增加。
