Cheruvanky T, Castro-Magana M, Chen S Y, Collipp P J, Ghavami-Maibodi Z
Am J Clin Nutr. 1982 Apr;35(4):668-70. doi: 10.1093/ajcn/35.4.668.
The present study shows that growth hormone administration to 30 growth hormone-deficient children significantly increased their hair zinc concentration (147.0 +/- 31.9 micrograms/ml before, and 168.7 +/- 30.4 micrograms/g after) and decreased their urinary zinc excretion (514 +/- 170 micrograms/g creatine before and 353 +/- 162 micrograms/g creatinine after), suggesting a role for growth hormone in zinc metabolism in children. Since the increase in hair zinc was similar to that found with testosterone on human growth, we speculate that at least some of the anabolic effects of growth hormone and androgens are mediated through their effect on zinc metabolism.
本研究表明，对30名生长激素缺乏儿童给予生长激素后，他们的头发锌浓度显著增加（之前为147.0±31.9微克/毫升，之后为168.7±30.4微克/克），尿锌排泄减少（之前为514±170微克/克肌酸，之后为353±162微克/克肌酐），这表明生长激素在儿童锌代谢中发挥作用。由于头发锌的增加与睾酮对人体生长的影响相似，我们推测生长激素和雄激素的至少一些合成代谢作用是通过它们对锌代谢的影响来介导的。
