Smith M B, Cauchi M N
Am J Hematol. 1982 Apr;12(2):121-30. doi: 10.1002/ajh.2830120204.
The factors responsible for the switch from gamma- to beta-globin synthesis, which occurs in man in the perinatal period, are still unknown. In this study the relationship of fetal maturity (as measured by gestation age and fetal weight) to changing rates of globin synthesis was analyzed. The relationship of rates of erythropoiesis to the switch was also analyzed. Rates of globin chain synthesis were studied in blood from fetuses from 10-41 wk gestation, in neonates up to 6 mo of age, and in a series of twins from 29-40 wk gestation. The beta/gamma-globin synthesis ratio in fetal blood remained relatively constant until 30-34 wk gestation when an increase in beta-globin production was observed. Adult levels of globin synthesis were present in neonates at 6-9 wk after birth. The gamma/alpha-globin synthesis ratio showed a reciprocal change, falling after 30 wk gestation. Globin synthesis ratios in fetuses and neonates from 32-41 wk post-conception showed a significant correlation with age (beta/gamma: p less than 0.001; beta/alpha:p less than 0.001; gamma/alpha: p less than 0.05), and there were significant correlations between the beta/alpha and beta/gamma synthesis ratios and weight (p less than 0.05 for both ratios). Globin synthesis ratios in 12 sets of twins from 29-40 wk gestation were generally within the normal range for gestational age. However, the switch to beta-globin production was more advanced than expected from weight for some of these babies.
在人类围产期发生的从γ珠蛋白合成向β珠蛋白合成转变的相关因素仍不清楚。在本研究中，分析了胎儿成熟度（以胎龄和胎儿体重衡量）与珠蛋白合成变化率之间的关系。还分析了红细胞生成率与这种转变之间的关系。研究了妊娠10 - 41周胎儿、6个月龄以内新生儿以及29 - 40周妊娠的一系列双胞胎的血液中珠蛋白链的合成率。胎儿血液中的β/γ珠蛋白合成比率在妊娠30 - 34周之前保持相对恒定，之后观察到β珠蛋白产量增加。出生后6 - 9周新生儿的珠蛋白合成水平达到成人水平。γ/α珠蛋白合成比率呈现相反变化，在妊娠30周后下降。妊娠32 - 41周的胎儿和新生儿的珠蛋白合成比率与年龄显著相关（β/γ：p < 0.001；β/α：p < 0.001；γ/α：p < 0.05），并且β/α和β/γ合成比率与体重之间也存在显著相关性（两种比率p均 < 0.05）。29 - 40周妊娠的12组双胞胎的珠蛋白合成比率通常在相应孕周的正常范围内。然而，对于其中一些婴儿，向β珠蛋白产生的转变比根据体重预期的更为提前。
