Schoen F J, Bernhard W F, Khuri S F, Koster J K, Van Devanter S J, Weintraub R M
Am J Surg. 1982 Apr;143(4):508-14. doi: 10.1016/0002-9610(82)90204-5.
Twenty-one postcardiotomy patients in cardiogenic shock, nonresponsive to pressors and intraaortic balloon, received temporary support with a pneumatically driven left ventricular assist pump, according to a strict National Institutes of Health protocol. Nine patients showed hemodynamic improvement after 91 to 190 hours; at least several of these patients had significant perioperative myocardial necrosis. Three patients remain well 39, 38 and 33 months after resuscitation. Eight of the patients died from hemorrhagic diathesis related to extended cardiopulmonary bypass times before hemodynamic improvement on left ventricular assist pump could be demonstrated. Correlation of myocardial biopsies taken at pump implantation in 15 patients and autopsy findings in nonsurvivors suggest that myocardial dysfunction has a reversible component that is related either to diminished compliance (probably due to edema) or to severe but reversible ischemic myocardial injury, or both. There was no evidence of thrombo- or biomaterials emboli or other pump-related complications.
根据美国国立卫生研究院的严格方案，21例心源性休克的心脏术后患者对升压药和主动脉内球囊无反应，接受了气动驱动的左心室辅助泵的临时支持。9例患者在91至190小时后血流动力学得到改善；其中至少有几名患者围手术期出现明显的心肌坏死。3例患者在复苏后39、38和33个月仍状况良好。8例患者在左心室辅助泵改善血流动力学之前，因体外循环时间延长导致的出血素质而死亡。对15例患者植入泵时所取心肌活检结果与非幸存者尸检结果的相关性分析表明，心肌功能障碍有一个可逆的成分，这与顺应性降低（可能由于水肿）或严重但可逆的缺血性心肌损伤或两者都有关。没有血栓或生物材料栓塞或其他与泵相关并发症的证据。
