Mateer J R, Clark M R
Ann Emerg Med. 1982 Apr;11(4):208-11. doi: 10.1016/s0196-0644(82)80500-3.
A case of severe lithium intoxication treated successfully with hemodialysis is presented. In addition to the common neurological manifestations of toxicity the patient demonstrated three rarely reported cardiotoxic manifestations: reversible first degree A-V block, intraventricular conduction delay, and prolonged Q-T interval. These findings demonstrate the need to include lithium intoxication in the differential diagnosis of drug overdose with prominent ECG changes. The pharmacology, presenting signs and symptoms, and current treatment modalities of lithium intoxication are reviewed.
本文介绍了一例通过血液透析成功治疗的严重锂中毒病例。除了常见的中毒神经学表现外，该患者还出现了三种罕见报道的心脏毒性表现：可逆性一度房室传导阻滞、室内传导延迟和QT间期延长。这些发现表明，在鉴别诊断伴有明显心电图改变的药物过量时，需要考虑锂中毒。本文还综述了锂中毒的药理学、表现出的体征和症状以及当前的治疗方式。
