Giebink G S, Heller K A, Harford E R
Ann Otol Rhinol Laryngol. 1982 Jan-Feb;91(1 Pt 1):20-4. doi: 10.1177/000348948209100106.
Relationships between ventilation of the middle ear (ME) system and pathogenic bacteria in the upper respiratory tract were explored in an animal model to better understand the etiopathogenesis of otitis media. Otitis media developed in 12 of 18 chinchillas inoculated intranasally with Streptococcus pneumoniae followed by bilateral ME deflation (negative pressure). Otitis media with effusion developed in 19 of 36 ears examined ten days after inoculation. The development of purulent effusion after ten days was highly correlated with persistent negative ME pressure for at least 48 hours after deflation, while most ears that developed serous effusion after ten days had normal ME pressure 48 hours after deflation. Tympanometric validation of the presence of absence of effusion and type of effusion was obtained ten days after inoculation. A low compliance tympanogram detected 90% of the purulent effusions and was 100% specific for this type of effusion. In contrast. three of four serous effusions were associated with normal pressure/normal compliance tracings suggesting that the physical characteristics or volume of ME effusion and/or the histopathology of the ME cleft are reflected i the tympanometric configuration.
在动物模型中探讨了中耳（ME）系统通气与上呼吸道病原菌之间的关系，以更好地理解中耳炎的发病机制。18只经鼻接种肺炎链球菌后双侧中耳放气（负压）的龙猫中，有12只发生了中耳炎。接种十天后，在检查的36只耳朵中，有19只出现了积液性中耳炎。放气后至少48小时持续的中耳负压与十天后脓性积液的发生高度相关，而十天后出现浆液性积液的大多数耳朵在放气48小时后中耳压力正常。接种十天后通过鼓室图验证了积液的有无及积液类型。低顺应性鼓室图检测出90%的脓性积液，且对这类积液的特异性为100%。相比之下，四分之三的浆液性积液与压力正常/顺应性正常的描记图相关，这表明中耳积液的物理特征或体积和/或中耳裂的组织病理学在鼓室图形态中有所体现。
