Vahouny G V, Roy T, Gallo L L, Story J A, Kritchevsky D, Cassidy M, Grund B M, Treadwell C R
Am J Clin Nutr. 1978 Oct;31(10 Suppl):S208-S210. doi: 10.1093/ajcn/31.10.S208.
The indirect effects of short-term (3-day) feeding of several types of dietary fiber and nonnutritive materials on the subsequent absorption of cholesterol has been investigated in thoracic duct cannulated rats. Absorption was studied at timed intervals over 24 hr after duodenal introduction of a tracer dose of cholesterol at least 20 hr after the last feeding. In animals fed for 3 days with diets containing cholestryamine, bran, or cellulose, cholesterol absorption was significantly less than in control animals maintained on rat chow. Rats fed for 3 days with an alfalfa-containing diet showed large variations in cholesterol absorption that were not significantly different from controls. However, after 5 weeks, rats on the alfalfa diet showed a marked reduction in lymphatic absorption of the tracer sterol. These indirect effects of cholestryamine and fibers on cholesterol absorption were not attributable to a common mechanism; i.e., differences in transit times that were not significant, or dirrect binding of bile acids and cholesterol by the test materials.
在胸导管插管大鼠中，研究了短期（3天）喂食几种膳食纤维和非营养物质对随后胆固醇吸收的间接影响。在最后一次喂食至少20小时后，向十二指肠引入示踪剂量的胆固醇，在24小时内按时间间隔研究吸收情况。用含消胆胺、麸皮或纤维素的日粮喂养3天的动物，其胆固醇吸收明显低于以大鼠饲料维持的对照动物。用含苜蓿的日粮喂养3天的大鼠，胆固醇吸收变化很大，与对照组无显著差异。然而，5周后，食用苜蓿日粮的大鼠示踪固醇的淋巴吸收明显减少。消胆胺和纤维对胆固醇吸收的这些间接影响并非归因于共同机制；即，转运时间差异不显著，或受试物质对胆汁酸和胆固醇的直接结合。
