胆固醇：从饮食到基因调控。
Cholesterol: from feeding to gene regulation.
机构信息
Department of Biology, University of Rome "Roma Tre", Viale Marconi, 446, 00146, Rome, Italy.
出版信息
Genes Nutr. 2007 Nov;2(2):181-93. doi: 10.1007/s12263-007-0049-y. Epub 2007 Sep 27.
Abstract
We present here a brief description of the path that cholesterol covers from its intestinal absorption to its effects exerted on gene regulation. In particular, the relationship between cholesterol and the protein complexes involved in the intricate gene regulation mechanism implicated in cholesterol homeostasis will be discussed. In addition, a new target role for the pharmacological interventions of one of these factors, the insulin-induced gene (Insig) protein, will be introduced.
摘要
我们在此简要描述了胆固醇从肠道吸收到对基因调控作用的途径。特别是，我们将讨论胆固醇与参与胆固醇稳态中复杂基因调控机制的蛋白质复合物之间的关系。此外，我们还将介绍这些因素之一，即胰岛素诱导基因（Insig）蛋白的药理学干预的新靶标作用。
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