Dobiásová M, Vondra K, Matousek V, Válek J
Atherosclerosis. 1982 Apr;42(2-3):251-61. doi: 10.1016/0021-9150(82)90155-1.
Changes in the rate of the plasma cholesterol ester production mediated by lecithin: cholesterol acyltransferase (LCAT, E.C. 2.3.1.43) were examined in 15 patients suffering from types II and IV HLP who had been treated for 14 weeks with etiroxate. Whereas the plasma cholesterol concentration decreased significantly only in the initial phase of the therapy, the rate of cholesterol esterification increased gradually and attained at the end of the study a value exceeding by 50% the initial level. The final fractional turnover rate nearly equalled that characteristic for the control group of healthy subjects, in spite of the fact that the concentration of plasma cholesterol in the diseased subjects was higher by 50-100%. Triglyceride concentration decreased only transitorily in the course of the therapy with etiroxate. It is concluded that etiroxate is likely to normalize the rate of cholesterol turnover in the endogenous pool.
对15例II型和IV型高脂蛋白血症（HLP）患者进行了研究，这些患者已用益多酯治疗14周，检测了由卵磷脂：胆固醇酰基转移酶（LCAT，E.C. 2.3.1.43）介导的血浆胆固醇酯生成速率的变化。尽管血浆胆固醇浓度仅在治疗初期显著降低，但胆固醇酯化速率逐渐增加，在研究结束时达到的值比初始水平高出50%。尽管患病受试者的血浆胆固醇浓度高出50 - 100%，但最终的分数周转率几乎与健康受试者对照组的特征值相等。在用益多酯治疗过程中，甘油三酯浓度仅短暂降低。得出的结论是，益多酯可能使内源性池中的胆固醇周转率正常化。
