英国曼彻斯特和日本名古屋的人工甜味剂与膀胱癌
Artificial sweeteners and bladder cancer in Manchester, U.K., and Nagoya, Japan.
作者信息
Morrison A S, Verhoek W G, Leck I, Aoki K, Ohno Y, Obata K
出版信息
Br J Cancer. 1982 Mar;45(3):332-6. doi: 10.1038/bjc.1982.59.
We have evaluated the relation between cancer of the lower urinary tract ("bladder cancer") and the use of artificial sweeteners, by means of case-control studies in Manchester, U.K., and Nagoya, Japan, areas where extensive use occurred 30-40 years ago. In each area, a broadly based series of cases (555 in Manchester, 293 in Nagoya) was interviewed and a series of controls (735 in Manchester, 589 in Nagoya) chosen from the general population. A history of use of sugar substitutes primarily saccharin, was not associated with an elevated risk of bladder cancer in either study area. Risk of bladder cancer did not increase regularly with frequency or duration of use of sugar substitutes. Data on dietetic beverages were not obtained in Nagoya. This exposure was not associated with a greater risk of bladder cancer in Manchester. The results of this study suggest that use of artificial sweeteners confers little or no risk of bladder cancer.
我们通过在英国曼彻斯特和日本名古屋进行病例对照研究，评估了下尿路癌症（“膀胱癌”）与人工甜味剂使用之间的关系。在这两个地区，30 - 40年前曾广泛使用人工甜味剂。在每个地区，我们对一系列广泛的病例（曼彻斯特555例，名古屋293例）进行了访谈，并从普通人群中选取了一系列对照（曼彻斯特735例，名古屋589例）。在这两个研究地区，主要使用糖精等糖替代品的历史与膀胱癌风险升高均无关联。膀胱癌风险并未随着糖替代品使用频率或使用时长而有规律地增加。在名古屋未获取有关营养饮料的数据。在曼彻斯特，这种暴露与膀胱癌风险增加并无关联。本研究结果表明，使用人工甜味剂几乎不会导致膀胱癌风险增加，或根本不会导致膀胱癌风险增加。
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