proprietary皮质类固醇软膏的稀释——评估相对临床效力的尝试。

The dilution of proprietary corticosteroid ointments--an attempt to evaluate relative clinical potencies.

作者信息

Gibson J R, Darley C, Kirsch J, Saihan E M, Neild V S

出版信息

Br J Dermatol. 1982 Apr;106(4):445-7. doi: 10.1111/j.1365-2133.1982.tb04538.x.

DOI:10.1111/j.1365-2133.1982.tb04538.x

Abstract

Ten subjects were assessed using the vasoconstrictor assay technique in a double-blind study in order to evaluate the potencies of several diluted and undiluted proprietary corticosteroid ointments. Results showed that clobetasol propionate 0.05% (Dermovate) ointment at a dilution of one part in ten (clobetasol propionate 0.005%) in white soft paraffin was equipotent with betamethasone valerate 0.1% (Betnovate) ointment; and no difference in potency was demonstrated between beclomethasone dipropionate 0.025% (Propaderm), betamethasone valerate 0.1% (Betnovate) and clobetasone butyrate 0.05% (Eumovate).

摘要

在一项双盲研究中，使用血管收缩测定技术对10名受试者进行了评估，以评价几种稀释和未稀释的专利皮质类固醇软膏的效力。结果显示，0.05%丙酸氯倍他索（得肤宝）软膏在白色软石蜡中按1:10稀释（0.005%丙酸氯倍他索）时，与0.1%戊酸倍他米松（倍他米松）软膏效力相当；0.025%二丙酸倍氯米松（适确得）、0.1%戊酸倍他米松（倍他米松）和0.05%丁酸氯倍他松（优力肤）之间未显示出效力差异。