利用表皮磷脂酶A2抑制作用监测局部用类固醇的作用。

Utilization of epidermal phospholipase A2 inhibition to monitor topical steroid action.

作者信息

Norris J F, Ilderton E, Yardley H J, Summerly R, Forster S

出版信息

Br J Dermatol. 1984 Jul;111 Suppl 27:195-203. doi: 10.1111/j.1365-2133.1984.tb15605.x.

DOI:10.1111/j.1365-2133.1984.tb15605.x

Abstract

The effect of several steroid creams on epidermal phospholipase A2 (PLA2) activity in symptomless psoriatic and normal epidermis was studied. The magnitude of PLA2 inhibition produced by the steroids was directly proportional to the initial level of the enzyme activity. This differential inhibition resulted in PLA2 activity approaching or attaining the normal range regardless of its initial level. Clobetasol propionate 0.05% (Dermovate) produced more enzyme inhibition than betamethasone valerate 0.1% (Betnovate) but there was no difference in inhibition between this latter steroid and clobetasone butyrate 0.05% (Eumovate). All were more inhibitory than hydrocortisone I% (Efcortelan).

摘要

研究了几种类固醇乳膏对无症状银屑病和正常表皮中表皮磷脂酶A2（PLA2）活性的影响。类固醇产生的PLA2抑制程度与酶活性的初始水平直接相关。这种差异抑制导致PLA2活性无论其初始水平如何，都接近或达到正常范围。0.05%丙酸氯倍他索（得肤宝）比0.1%戊酸倍他米松（倍他米松戊酸酯）产生更多的酶抑制作用，但后一种类固醇与0.05%丁酸氯倍他松（优力肤）之间的抑制作用没有差异。所有这些都比1%氢化可的松（艾氟龙）更具抑制性。