Herrmann K, Haustein U F, Böhme H J, Lohrisch I
Br J Dermatol. 1982 May;106(5):523-8. doi: 10.1111/j.1365-2133.1982.tb04554.x.
The activities of five lysosomal hydrolases were determined fluorometrically in the serum of patients with systemic sclerosis (PSS), systemic lupus erythematosus (SLE), dermatomyositis (DM), rheumatoid arthritis (RA), or Raynaud's disease (RD). In PSS the beta-galactosidase activity was significantly increased compared with controls and the other connective tissue diseases. The beta-N-acetyl-glucosaminidase was significantly increased in PSS, SLE and DM. In PSS both enzymes were more active in the early stage of the disease than later. These changes of enzyme pattern seem to be a relatively reliable marker for the differential diagnosis of PSS compared to other connective tissue diseases, especially for RD, in which the beta-galactosidase activity was significantly decreased. Further work is required to determine whether these polysaccharide-degrading acid hydrolases play a role in the pathogenesis of PSS.
采用荧光法测定了系统性硬化症（PSS）、系统性红斑狼疮（SLE）、皮肌炎（DM）、类风湿性关节炎（RA）或雷诺病（RD）患者血清中五种溶酶体水解酶的活性。与对照组及其他结缔组织病相比，PSS患者的β-半乳糖苷酶活性显著升高。PSS、SLE和DM患者的β-N-乙酰氨基葡萄糖苷酶活性显著升高。在PSS患者中，这两种酶在疾病早期比晚期更活跃。与其他结缔组织病相比，尤其是与β-半乳糖苷酶活性显著降低的RD相比，这些酶模式的变化似乎是PSS鉴别诊断的一个相对可靠的标志物。需要进一步开展研究以确定这些多糖降解酸性水解酶是否在PSS的发病机制中发挥作用。
